CNS Question (Huntington’s Disease)

A 32 years old male patient has recently stopped going to his job and is complaining of depression. He is having difficulty remembering things and focusing on tasks. He mentions that he has noticed involuntary ticks in his fingers. He is very worried for his health.

You suspect Huntington’s disease. What is the most probable neurotransmitter issue that is causing ticks?

A. Reduced dopamine release in the neostriatum.
B. Increased dopamine release in the neostriatum. C. Reduced GABA release in the neostriatum.
D. Increased GABA release in the neostriatum.
E. Reduced acetylcholine release in the frontal cortex.
F. Increased acetylcholine release in the frontal cortex.

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