Tag: DrBivek

Insult to liver on long run can cause fibrosis of the liver and formation of nodules ,which is termed as liver cirrhosis. Liver cirrhosis is a chronic condition of the liver in which there is fibrosis and formation of nodules. The normal architecture of the liver gets distorted and patient presents with number of clinical feature.

Causes of Liver cirrhosis include:
1. Infection: Hepatitis B, C, D
2. Toxins: Alcohol
3. Cholestasis
4. Vascular
5. Metabolic
6. Genetic
7. Cryptogenic

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EXPLORING DIURETICS

Diuretics forms one of the base pillars in treating hypertension and edema. These groups of drugs increases  rate of urine flow. Based on their mechanism of action their efficacy varies. Before moving into diuretics I would recommend to revise renal physiology which will make it easier to get deeper and clear concept of mechanism of diuretics. In this section I will not go into details of each and every diuretics, I would rather try to provide concept and differentiating feature based on mechanism of action and adverse effects.

ADVERSE EFFECTS OF DIURETICS

Efficacy

Class of diuretics Example
Carbonic Anhydrase Inhibitors (CAI) WEAK Acetazolamide
Osmotic diuretics WEAK Mannitol
Loop diuretics HIGH Furosemide
Thiazide MEDIUM Hydrochlorothiazide
Potassium sparring diuretics WEAK

Amiloride (Sodium channel inhibitors)

Spironolactone (Aldosterone receptor antagonist)

Lets revise different section of nephron, (see the figure)

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