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Mast and Basal Cells Duration: 1:15:09
Immunology /

Learning Objectives

  1.  Review of  the cells involved in immune system. 
  2.  Granulocytes (Basophils and eosinophils).
  3.  Difference between a basophil and a mast cell. 
  4.  Recap of production of basophils. 
  5.  Chemicals that cause increase in their production. 
  6.  Structure of basophil/mast cells.
  7.  Primary functions of the contents in their granules. 
  8.  Concept of allergin and antigen. 
  9.  Genetic disposition to allergic reactions.
  10.  How IgE antibodies mediate anaphylaxis. 
  11.  Role of cGMP in relese of histamine.  The mechanism of action of histamine. 
  12.  cAMP and its function in membrane stabilization of mast cells. 
  13. The mechanism of releases of preformed chemotactic factors in the acute phase. 
  14. Different lipid mediators of anaphylaxis reaction.
  15. Role of leukotrienes in mediating the late phase anaphylaxis reaction.
  16. Potential effect of leukotriene B4 in causing inflammation.
  17.  The slow-reacting substances involved in anaphylaxis.
  18.  Mechanism of an anaphylactoid reaction.
  19. Various triggers for allergy.
  20. Role of eosinophils in reducing allergic reaction and secondary harmful effects of eosinophils on the body. 
  21. Eosinophils: basic structure and properties. 
  22.  Functions of eosinophils in helminthic infections and antibody-dependent cellular cytotoxicity (ADCC). 
  23.  An overview mechanism of ADCC.
  24.  The possible role of eosinophils in asthma. 
  25.  Consequences of activation of eosinophils in case of asthma. 
  26. Different inflammatory chemical mediators released from eosinophils.
     

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